Scientist 1, Receptor Pharmacologist

Who We Are: MapLight Therapeutics is a clinical stage biotech company that focuses on drug discovery for central nervous system disorders. We combine cutting-edge technologies including optogenetics, in vivo physiology, and spatial transcriptomics to identify novel drug targets and develop effective therapies to address psychiatric symptoms.

What You’ll Do: MapLight is looking for an experienced and creative Receptor Pharmacologist to accelerate the development of internal in vitro pharmacology capabilities to further our pre-clinical pipeline. Reporting to the Head of Molecular Biology, this position will also enable mechanism-of-action studies of MapLight drug targets which will provide foundational support for progressing new therapies into clinical development.  


  • Interface with drug discovery teams and conduct SAR on MapLight compounds and enter data into the MapLight database  
  • Design and perform pharmacological assays to assess the activity, selectivity, and potency of drugs 
  • Critically evaluate in vitro biology data coming from CROs 
  • Develop creative solutions to answer pressing questions around lead targets 


  • PhD in Pharmacology, Cell Biology, Biochemistry or relevant scientific field with 1+ years post-degree experience 
  • Breadth-of-knowledge in pharmacology and GPCRs  
  • Experience screening compounds with in vitro assays 
  • Experience with multiple GPCR signaling assay technologies 
  • Experience with liquid handlers, plate readers and data management software  
  • Ability to work as a part of a multidisciplinary team  
  • Experience working in on CNS targets
  • Excellent verbal and written communication skills 
  • Track record of publications in relevant field 
  • Proficiency in a statistical programming language such as R 
  • Experience with neuronal in vitro models 


MapLight is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.


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