Find a trial near you

MapLight Therapeutics is recruiting patients for IRIS, a Phase 2 clinical trial evaluating ML-004, the company’s lead clinical compound for patients with Autism Spectrum Disorder. The study will assess whether there is an impact of ML-004 treatment on the core social communication deficits and on the associated features of irritability in ASD. 

The randomized, double blind, placebo-controlled study will evaluate the efficacy and safety profile of ML-004 in up to 150 adults and adolescents with ASD. The study will be conducted in the United States, Australia, and Canada, and is fully funded by MapLight.

For more details on the study, and to contact participating sites near you, visit the study page at

Study Sites Currently Screening and Enrolling Patients

Country State / City Physician Institute
United States Alabama / Dothan Nelson Handal-Thome, MD Harmonex Neuroscience Research
United States Arizona / Phoenix Christopher Smith, PhD Southwest Autism Research & Resource Center
United States California / San Francisco Robert Hendren, DO University of California, San Francisco
United States Washington DC Adelaide Robb, MD Children's National Health System
United States Florida / Orlando Morteza Nadjafi, MD APG Research, LLC
United States Florida / Tampa Daniel Fallon, MD USF Psychiatry and Behavioral Neurosciences
United States Illinois / Naperville Riaz Baber, MD AMR-Baber Research Inc
United States Massachusetts / Lexington Christopher Keary, MD Mass General Hospital's Lurie Center for Autism
United States Michigan / Bloomfield Hills Richard Jackson, MD Neurobehavioral Medicine Group
United States Missouri / Columbia Benjamin Black, MD U. Missouri, Thompson Center for Autism & Neurodevelopmental Disorders
United States New Jersey / Berlin Steve Glass, MD Hassman Research Institute
United States New York / Staten Island Matt DiBuono, MD Richmond Behavioral Associates
United States Pennsylvania / Media Shivkumar Hatti, MD Suburban Research Associates
United States Texas / Houston Lawrence Ginsberg, MD Red Oak Psychiatry Associates, PA
United States Texas / San Antonio Jerry Tomasovic, MD Road Runner Research, Ltd.
United States Utah / Draper Reid Robinson, MD Cedar Clinical Research
Australia New South Wales / Camperdown Adam Gaustella, Prof Brain and Mind Centre
Australia Queensland / South Brisbane Helen Heussler, MBBS Children's Health Queensland Hospital and Health Service
Australia Queensland / South Brisbane Catherine Franklin, MBBS Mater Research
Australia Victoria / Parkville David Amor, MBBS The Royal Children's Hospital, Murdoch Children's Research Institute
Canada British Columbia / Kelowna Euguene Okorie OCT Research ULC